Can You Trust Your Doctor?

In my case, I don’t think so, but I’m hoping in your case that you CAN trust your doctor.

For those of you that have been following my blog posts, I have been out of insurance (but now have it) for the past three years.  Losing my insurance, because my husband lost his teaching job and we could not afford Cobra, was a blessing to a certain extent because it forced me to try alternative methods, and I found some excellent ones, including my two favorite, Low Dose Naltrexone and Serracor-NK.  Raising my Vitamin D levels and B12 have also been some excellent choices of mine along with other great choices like fish oil, etc., all improving my quality of life.  RA is very hard to control.  Just talk to anyone who’s on the conventional meds and you will find that many still haven’t found the right cocktail, and most are still experiencing joint damage despite taking DMARD’s.   I’m certainly not against drugs, but I will say that taking alternatives has opened my eyes to the possibility of healing my body rather than just suppressing the disease.  So now that I have insurance, it means for me, going back to the doctor, not to see what my choices are, but to get blood work done, x-rays and let the doctor know what choices I’m in favor of.

I hadn’t seen my favorite nurse in several years.  She gave me a giant hug.  “Wow, you look great!” she said.  She asked me what I was taking for my RA.  I told her supplements, but that I wasn’t on any drugs except for the occasional prednisone.  She said, “Wow, it’s really working, you look fantastic!”

Unfortunately, my Rheumatologist experience was definitely a poor one.  Before this Rheumatologist, I had researched and found a much older gentleman who became my Rheumatologist for approx one year.  He was open-minded, not against antibiotic therapy, not against supplements or icing my arm which proved to be the most beneficial in reducing the inflammation in my left forearm in particular, and he had enough experience and knowledge that I felt I had found a good doctor.  When I saw him for the first time, he ordered one x-ray of one hand.

After one year however, he retired.  He told me he found an excellent replacement, a young woman graduating from UCLA.  I was disappointed that I would no longer have my old doctor, but I was open to having a new doctor, especially a woman.  When I met her, she seemed nice enough.  She was young and beautiful and very friendly.  She sent me to x-rays and for blood work.  When the radiologist told me I had 30 x-rays to get done, I thought, “Really?”  At that time, I was not as forthright with my care.  I didn’t put my foot down and say, “that’s way too many.”  Instead, I let the x-rays happen, including one to my throat (which I have hypothyroidism and that’s never a good idea) and including one to my pelvis, (I am of child-bearing age and that’s never a good idea either).  And then I lost my insurance and I got a bill of $700 for all my x-rays.  I fought the bill for over 6 months, and eventually the insurance took care of it.  I was unhappy with the doctor because you should never expose yourself to that much radiation.  X-rays are cumulative, and even though there’s no clear evidence of how much is too much, I’m on a healing path, not a path of increasing the toxins in my body.   And having had a doctor, a great doctor, who only ordered one x-ray, and one later on to compare, I knew that 30 x-rays were approximately 29 too many.

What I find interesting, is that when you look for information on the internet, it’s always, “Well you’re exposed to radiation all the time from natural sources.”  But what makes this ok?  Why would you then want to increase your exposure?  Two wrongs don’t make a right, right?  It’s easy for doctor’s to poo poo the fear of two many x-rays, while billing your insurance, putting money in their pocket, but let me just say this, a close relative of mine who is a radiologist, was quite upset to hear that I was exposed to 30 x-rays before and thought my doctor was a quack and just trying to pay off her college loans.  He chooses not to get x-rays whenever they aren’t absolutely necessary.

I hadn’t seen my new Rheumatologist in almost 3 years and I was convinced that she had probably learned a thing or two since I had last seen her.  Or maybe she would at least know not to give ME so many x-rays.  I was open to the possibility that I just needed to give her a second chance.  Maybe before, she just didn’t know.  She was surprised how flexible I was and how little inflammation and deformity I appeared to have.  So there you have it, my supplement regimentation is working to a certain extent.

At the end of the apt., she asked if I was open to getting my hand x-rayed.  “Sure”, I said, “but please I don’t want any x-rays of my thyroid or ovaries because that can be very harmful.”  She didn’t say anything, so I wondered if she knew what I was referring to and sent me down for blood work and x-rays.

When I saw the technician, he said, “Ok, 18 x-rays today.”  I said, “What?  How can that be?”  And he explained that there were several of each hand, several of each feet, etc.  At first I thought, “well ok, it’s just the hands and feet.”  But thinking back to how many my previous Rheumatologist exposed me to, (totaling two) and considering just 3 years ago, this doctor had exposed me to 30, I told the technician I’d pass.

I walked back to my Rheumatologist office and handed the paper ordering the x-rays to the nurse and said, “Tell her this is simply too many” and left.

I just figured it was time for me to find a new Rheumatologist.  And so my quest begins….

The Blame Game

From experience when it comes to having RA, it’s easy to play the blame game when a flare happens.  You ask, “what caused this?”   And if it’s not you asking the questions, then perhaps it’s your spouse, your family member or your co-worker.  Most of the time,  you don’t know the answer of what causes a flare.  If you did, you’d stay away from it.  You’d stop talking to your mother if that meant you’d never have RA again.  And sometimes you have a pretty good suspicion of what just threw your body into wicked pain and disability.

I was already feeling run down but I had to make it to a 40th birthday party.  It was important,  I couldn’t miss it.  If I could do it all over again, I’d still have gone but I would definitely change a few things.

I was human.  I made typical mistakes.  I pushed myself too hard.  I drank too much,  I danced too much.  I got too little sleep.  I ate all the wrong foods the next day:  soup with noodles, bread and then pizza.  It was all to calm down the acids in my stomach, quiet the nausea I had and the dizziness from drinking WAY too much and also comfort myself because I felt so ill.  My pounding head was keeping me from thinking any rational thoughts anyway.  I’m sure my headache wasn’t just from the hangover.  It had been hurting for days before I made it official.  My RA wasn’t bothering me (yet) probably because alcohol thins the blood.  The funny thing is, I had been avoiding alcohol for quite some time.  So when the party came, I decided to give in a little.  And you know, once your inhibitions are down, this is when your choices can really go out the window.  In the late evening when I reached for another cocktail rather than water, that’s when things became tipsy-turvy.  And when that sweet drink went down and I was STILL thirsty, I reached for one more.  Of course at this point, I was too buzzed to talk myself out of it.  I could still stand.  What was the harm in one more drink?  Actually, my mind didn’t even go there.  I just thought, “I’m thirsty……got liquid?”

If only the hangover could happen right then, so you can stop the drinking.  Instead, you just feel great and numb to any rational.  I didn’t drive home of course, but as a passenger, I felt like hanging my head out of the window like a dog.  Of course, it would have been for relief, not for enjoyment and yes, my tongue would have been sticking out.  To make matters worse, I’m one of those people that actually holds everything in, no matter how sick I am, poisoning my body far worse than most.  Most people share in the ritualistic experience of expelling the poisons.  I on the other hand, could probably swallow hydrogen peroxide and keep it down.

That was Saturday.

Sunday was spent nursing my hangover.

When Monday came around I was in a horrific flare.  I knew it was everything that I had done wrong:  too little sleep, all the wrong food, coupled with all the sugar from the alcohol and did I mention, alcohol is a poison?  Oh yeah, you know that already.  Bread, pasta, everything I ate that day was inflammatory, at least, according to my reading it is (current pick is “The Inflammation Free Diet Plan”).  And here in lies the blame game.

So yes, that morning when I got up to go to work and my stiff neck, rocks under my feet and wrists that felt like they were in a torture device trying to pull them apart, were all slowing me down and keeping me from getting to work on time, I played the blame game.  I blamed myself for making wrong decisions that night and the next day.  I blamed myself for the sleepless nights on the weeks before the party that made me run down.  I blamed myself for all the exercise I skipped for a couple of weeks because I simply felt tired and lazy.  I blamed myself for all the supplements I forgot to take.  And I went into work feeling angry and frustrated for all the things I’m suppose to avoid and all the things I’m suppose to do to quiet my condition.  And I felt embarrassed that maybe I could have avoided this.  There was no skip in my step, no ambitious agendas ahead of me.  It’s not enough to have RA, you’re also suppose to be great at eating all the right foods, getting good sleep, living a stress free life and getting exercise, haven’t you heard?  It’s tiring avoiding things and trying to stay on the straight and narrow.  It’s tiring taking supplements.  It’s tiring just knowing that there’s never a real break from any of it.  And yes, I still have yet to try Yoga.

I’m still in a flare but at least I can turn the steering wheel now without wincing (as much) and without the staccato jerky turn only a person who probably shouldn’t be driving might do.  At least I can view my computer screen again without the blurry vision that accompanies me when I’m in a really bad flare.  And at least I can finally put my arms to my sides without feeling like my wrists are being pulled off.  And in no way does this flare compare to ones of the past where the pain and disability made me crazy.

I’m still tired however, hoping things will somehow change, hoping one day I’ll reach remission.  I think I’m learning, slowly but surely. ……….. Oh hey, will you pass that bread?  ……..but I will probably never be perfect.  After all, I am human.

My first journal entry on Daily Strength: Aug 8, 2007

To those of you who wake up every morning in pain, or sit for a few minutes and have trouble getting up……or feel weak, tired…. depressed…….. or have people who don’t really understand……… to those of you who keep trying everything you can to get rid of your flare, hoping to just get back to your normal self……….. and to those of you who are saddened that you can’t do the things you use to do……..like pick up a child, or open up that bottle of water, or take off your bra. Yes, there are days I can, but plenty of days that I can’t. And to those of you that read online things like, “arthritis is possibly caused by poor diets, lack of exercise, unhealthy lifestyle…etc.” and get frustrated because you exercise everyday, eat healthfully and always have, etc…………………

I can relate………and, I want to hear from you!!!

I’m certainly not going to loose hope that I can’t get back a semi normal lifestyle. Plus, with medical advancements, you just never know.

But for now, I continue on my journey wanting to hear from all of you……..in our quest to improve the life we have and to share with each-other R.A. which I truly believe no one understands until you have it.

For instance, I love to exercise and I always have. When I exercise I do feel better. But during a time when I’m not having a flare……..I still can’t do….say… yoga. There are just simply things I can not do. I can’t bend my wrists like I use to……and I’ve lost a lot of strength. When I’m not in a full blown flare, I excersize as much as possible while I can. When I am going through a flare (which I am now) and just so you know, I’ve been on prednisone for 8 months………and now I’m on methotrexate for the first time as well as still on the pred. I’m having of course nausea and hair loss. It sucks and I’m not sure I really want to be on this medicine. At first I thought I did, but I just don’t know anymore…….even though I don’t have any better ideas. But anyway, exercise baffles me. Because now that I’m flaring again hard core, I’m still going to the gym. When I get there it takes all of my effort to get myself moving. But once I start moving, it gets a bit better……and continues to improve slightly (never like it use to) but enough that I’m feeling more confident and happy. The moment I stop…..like literally take a step off the elliptical, I feel as though I’m right back to normal again, meaning pain and stiffness, and it takes all of me to get myself out of the gym and back in the car. Sometimes I have to pull on my legs to get them up on the elliptical.

How many of you have tripped on your way into the shower because it’s too hard to lift your legs? Or how about…..how many of you have worried about your driving skills now that it’s difficult to turn your head and the steering wheel? Any of this sound familiar?

On my last day to drink for a long time which was Sat when I went to this amazing wedding. I drank too much of course, champagne, etc. I exercised that day already so I could feel better in the evening. I took prednisone and plenty of pain killers. I know, I know, terrible on my liver. I didn’t start Methotrexate until last night which was on Doctor’s advice………he knew I’d be bingeing on sat. Anyway, my point: So there I was at the wedding, tipsy, dancing, and having a great time…..the most limber and energetic I had been in a while. And a woman I know who is a friend of mine and knows of my R.A………we were walking partners and with my last flare I had to stop the early mornings… Anyway she said, mockingly, “Your rheumatoid isn’t bothering you now is it?” and it felt so……….you know, like you must be faking this sort of thing.

O.k. now you heard me vent. Ahhhh, this is what a journal is all about.

Health before Wealth

Recently I was talking to my mom about the newest thing I’m thinking of trying. It’s suppose to balance the pH of your water, along with add electrolytes and minerals. (see link) She asked, “How can you afford to take all of these things?”

The truth is, financially I can’t really. I’m stretched as thin as a rubber band, ready to break at any moment. These are hard, economical times.

On the flipside, can I afford to NOT keep trying new therapies in hope that remission will soon be giving me a high five at my doorstep? Sure I’m feeling great in a sense that I’m completely functional with RA. But as long as I’m not in remission, there’s still damage being done. I’m thinking long term. It’s the same as keeping up on your teeth cleaning. If you don’t, you could end up with some serious tooth decay, along with heart conditions and toxins invading your body. What kind of damage is happening to my hands long term? And there’s no guarantee with conventional drugs either that you can skip out on the deformities. Just clue into a recent post and you’ll see that hand deformity is just like the disease itself in that it varies from person to person. So you have to do your best to get inflammation under control no matter what you’re taking. Even if you’re taking DMARD’s and Biologics, you have to consider that eating right and exercising would be a wise, helpful choice since these medications can raise cancer risks, among other things. Our bodies are long term investments.

From time to time expense comes up as a topic in my RA support group. The idea of going organic, buying fresh food vs packaged, and taking supplements that can improve overall health seems too expensive to some. Most people embrace the burden of the extra costs, but a few need encouragement that long term, investing in the right foods and supplements will save money. This is particularly tough when a lot of us, including myself are living paycheck to paycheck. What you pay now at the grocery mart will help determine the costs of your future medical bills. Just like I am spending money on supplements, rather than movies or haircuts, I’m figuring that the money I spend now could make for a less expensive health bill in the future. Not only that, but the better I feel and the more that I can do, the better chance I have at making more money in the future, simply because I’ll be able to keep up a career and hopefully advance in that career.

So my motto is, when you’re trying to decide what to eat for lunch and your choice is a hamburger on the doller menu or that organic salad with grilled, free range chicken that were raised without antibiotics….. choose the latter. Because in my opinion, you’re going to be paying for your health in one way or another.

The Ripple Effect

Getting older is tough enough.  Watching your body change as you get older is a gradual process.  A gray hair here, a gray hair there.  A wrinkle here, a wrinkle there.  As the days move forward, at least you know everyone else is in the same boat.

But getting older with an autoimmune disease, in my opinion, is far more difficult.  You plunge head first into a scary world, and you imagine this must be what it feels like to be 90.  Losing abilities, taking pills daily, watching your body change at a very fast rate can be not only frustrating and painful, but detrimental to your mental health.  Each day is different.  You might notice new rashes on your skin, new bumps or bruises, or another task left uncompleted because of lost ability or weakness.  I remember clumps of hair falling out in the shower.  I felt sort of like a cancer patient.  The kinds of things you go through are just not meant for daily conversations.  So you feel alone and trapped in your own skin.

Luckily however, I have been able to get my Rheumatoid Arthritis under control with alternative medications that don’t have side effects.  My hair no longer falls out in clumps.  I rarely get new bumps or rashes.  And I am able and agile enough to once again live a full and productive life.

But that’s not why I’m writing this post.  This post is about the unknown and that gripping fear that although everything seems ok at the moment, the likelihood that more problems are in your future, especially as you grow older, is likely to occur.  And don’t say that I’m living life with a glass half-empty.  I am optimistic that whatever arises, I’ll be able to handle and possibly even get control of by taking more supplements.  But my point is, is that it is likely that if you get one autoimmune disease, there may be more to follow.

My first autoimmune disease was a skin disease.  It’s located on my shins and called Necrobiosis Lipoidica.  At first I was told it was Granuloma Annulare and the doctor showed me a picture of a woman with it all over her body.  This conclusion of course, was horrifying to me because for the next five years, I worried I’d be covered with shiny, scaly scars.  Fortunately, the doctor was wrong and instead, I was diagnosed later with Necrobiosis Lipoidica, which is a skin disease that only affects the shins.  Both skin diseases usually accompany diabetes, so the doctor was confused why not only did I not have diabetes, but it did not run in my family.  Later, in my research of Rheumatoid Arthritis, I learned that Necrobiosis Lipoidica sometimes is associated with RA.  Around those same years that I developed this, I also got pleurisy, which is a painful inflammation of the lining between your lungs and your ribs.  Antibiotics seemed to clear it up and it was probably a result of living in such polluted air.  Pleurisy, however,  is a frequent symptom of Lupus and it sometimes accompanies RA.  Fast forward four years and I’m diagnosed with Hypothyroidism.  My gynecologist caught it, otherwise this would have probably gone on for years without me realizing.  Then seven years later I was diagnosed with RA.

The reality is, most people with an autoimmune disease like RA or Lupus, usually have many more autoimmune diseases.  It can be a ripple effect.  Whether it’s the diseases themselves, the lifestyles that accompany the diseases, or the medications, more and more seem to pile up.  I’m glad to be on alternative medications because I know I’m taking things that might just possibly reverse the disease process.  But there’s always that side of me, that terrified side, like a voice in the back of my head that says, “What’s next?”  This time at least, I know that I’m doing all that I can do.  I’m armed with knowledge.  I’m taking supplements that improve my health.  I’m eating better, sleeping more and consuming fewer toxins.  There’s nothing more that we can do besides enjoy every day for what it is, knowing life is uncertain, so whatever each day may bring, let it be the best that it can be.

Elizabeth Gilbert: Olé!!

I got this video from “Creative Chronic Babes” and found it appropriate for just about anyone. Elizabeth Gilbert is funny, soothing and inspiring. Although you may not end up ROFL, it’s still a must see if you enjoy a great speaker and want to feel inspired. Sit back and enjoy.

Lactoferrin, A Miracle Supplement

LactoferrinI have always been on the lookout for a natural supplement that can do what an antibiotic does. But wait, Lactoferrin does so much more. The amount of information out there on Lactoferrin is unbelievable, and I’m wondering why it’s taken until now for me to even hear about it. Read on and you will discover Lactoferrin is a supplement you should consider if you want to fight viruses, cancer, autoimmune diseases, and inflammation in general. And for those who are tired of taking supplements or popping any more pills, I have the answer for you too. Bioactive Whey is a great source for Lactoferrin. Scoop it up and serve it in your favorite drink. Your immune system will thank you later….

“It’s an effective anti-oxidant, anti-fungal, anti-bacterial, anti-viral, anti-inflammatory, anti-cancer agent and immune-boosting powerhouse. The FDA felt confident enough to approve its use as a spray on beef carcasses to kill E. coli 0157:H7, a particularly virulent disease-causing bacteria.”-Raw Milk Facts

Although further research needs to be made, Lactoferrin is believed to be helpful for the lungs whether they are inflammatory conditions such as Sarcoidosis, Cystic Fibroisis, or cancerous lungs. “Lactoferrin is a protein that is found naturally in milk, tears and saliva and can stop the growth of bacteria by preventing them forming ‘biofilms’ (when bacterial cells group together on a surface, such as the lining of the lung).”-European Medicine’s Agency

Lactoferrin (LF), also known as lactotransferrin (LTF), is a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucoses……….The combination of iron and lactoferrin in mucosal secretions modulate the ability and aggregation of pathogenic bacteria, and inhibit both bacteria and viruses by binding to host cells/viral particles. This inhibits the ability of bacteria and viruses to attach to cell membranes. It is also an antifungal agent.”-Wikipedia

If you’re taking drugs like Enbrel, Orencia, Humira, Amevive, Epogen Remicade or Herceptin, these are inhibitors of tnf-protein. The problem with these drugs is they come with a wide range of side effects, including some rare, but very serious ones which can be even more serious than the condition that you’re taking them for. “Lactoferrin released at sites of inflammation interacts with mononuclear cells (16) and suppresses the production of inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha ) and interleukin-1 (IL-1) (6).”-Clinical and Vaccine Immunology

The possibilities of Lactoferrin seem endless.

Immunity:

“Lactoferrin is found throughout the human body and occurs in all secretions that bathe mucous membranes such as saliva, tears, bronchial and nasal secretions, hepatic bile, pancreatic fluids, and is an essential factor in the immune response. Lactoferrin is concentrated in oral cavities where it will come in direct contact with pathogens (i.e. viruses, bacteria, etc.) and kills or greatly suppresses these pathogens through a variety of different mechanisms. In fact, there are specific receptors for lactoferrin found on many key immune cells, such as lymphocytes, monocytes and macrophages, and is known to be directly involved in the upregulation of natural killer (NK) cell activity. “-Life Extension

Anti-Viral:

“Lactoferrin has been found to both directly and indirectly inhibit several viruses that cause disease in humans. It directly inhibits viruses by binding to viral receptor sites, thus preventing the virus from infecting healthy cells. For example, in vitro studies have found that lactoferrin strongly binds to the V3 loop of the gp120 receptor on HIV-1 and HIV-2, resulting in inhibition of virus-cell fusion and entry of the virus into cells.10 In addition, lactoferrin indirectly kills or inhibits viruses by augmenting the systemic immune response to a viral invasion. It’s interesting to note that there is a systemic deficiency of lactoferrin in people with HIV infection.”-LifeExtension

Anti-Cancer:

“Perhaps one of the most promising uses for lactoferrin may be in its potential as a nontoxic adjuvant cancer treatment agent. Extensive in-vitro (test tube) and in-vivo research with animals has shown lactoferrin to be a powerful anti-cancer agent.”-LifeExtension

Colon and Lung Carcinomas:

“Sekine et al. have demonstrated in vivo prevention by bovine LF (bLF) of aberrant crypt foci (ACF) and colon carcinomas in rats pretreated with azoxymethane and Bezault et al. found that injection of human lactoferrin (hLF) markedly inhibited tumor growth of solid tumors derived from v-ras transformed fibroblasts and a methl-cholanthrene-induced fibrosarcoma as well as lung colonization by the B16-F10 melanoma in an expermintal metastasis mode.”-Clinical & Experimental Metastasis

Anti-microbial:

“One study looked at lactoferrin as a “natural antibiotic” and found that lactoferrin both in-vitro and in-vivo strongly inhibited the toxic bacteria helicobacter pylori. They stated “It is concluded that bovine (cows) lactoferrin has significant antimicrobial activity against helicobacter species in-vitro and in-vivo.”(16) Another study using both in-vitro and in-vivo methods added lactoferrin to the drinking water of mice and subjected them to the toxic microbe staphylococcal. The study found that the mice getting the lactoferrin as 2% of calories reduced kidney infections by 40% to 60% and reduced bacterial counts 5- to 12-fold. They concluded “the results suggest a potential for the use of lactoferrin as natural anti-bacterial proteins for preventing bacterial infections.”(17)-LifeExtension

Antioxidant: “‘Several studies suggest lactoferrin reduces oxidative stress. Diseases such as cancer, heart diseases and AIDS are all closely related to oxidative stress either as a causative factor or as a factor in progression of the disease. One study that examined the role of whey proteins, multifermented whey proteins and lactoferrin in oxidative stress made the bold statement, “We can conclude that whey protein, lactoferrin and multifermented whey are good candidates as dietary inhibitors of oxidative stress and should be considered as potential medicinal foods in various pathologies as HIV infection and cancer.'(21) “-LifeExtension

Skin:

  • Repairs and purifies the skin
  • Reduces itching
  • Increases the skin’s defence mechanism
  • Reduces red and burning skin

Healthy Gums:

“A wide range of research institutions are focusing on and conducting research into lactoferrin. Through exhaustive gene expression analysis and administration studies, Lion was able to find out that lipopolysaccharide (LPS), a pathogen produced by periodontal bacteria, not only stimulates the progress of periodontal disease but also increases the level of cholesterol and triglycerides in the blood, a condition known as “dyslipidemia,” which is one form of metabolic syndrome*. “-LION

Anemia:

“It is relevant in the battle against anemia because it appears to improve iron absorption from food and helps transport this essential mineral to wherever it’s needed.”-HF

Candida and Ecoli:

“Lactoferrin possesses two known direct anti-microbial peptides called lactoferricin B and lactoferrampin. Researchers exposed cells of Candida albicans and E. coli to lactoferrin and then watched what happened under a high power laser-scanning microscope. The lactoferrin was taken up into the cell membranes of both organisms within a few minutes, and then proceeded to disrupt the integrity of their cell membranes, which either kills them directly or enables the immune system to fight an easier battle. The researchers observed that it was the lactoferrampin peptide that disturbed Candida, whereas the lactoferricin B disrupted E. coli. This indicates that lactoferrin uses multiple strategies depending on the type of problem.”-Wellness Resources

Arthritis:

“We have recently shown that resistin is a key mediator of arthritis accumulating in the inflamed joints and exerting its pro-inflammatory properties independently of TNFalpha. Here we evaluate neutrophils as a cellular source of resistin. Human neutrophils were subjected to subcellular fractionation where the presence of resistin was assessed using western blot, ELISA, and mass spectrometry. Presence of resistin on the neutrophil surface was visualized by flow cytometry. More than 95% of the neutrophils in circulation and in synovial fluid express resistin on their surface. Stimulation of mature neutrophils with fMLF induced release of resistin into supernatants and increased expression of resistin on the surface. Resistin is mobilized simultaneously with lactoferrin, a protein found in specific granules, and with granule-stored CR3/CD11b. Subcellular fractionation of human neutrophils demonstrated the presence of resistin in azurophilic and in specific granules. Here we show that neutrophils have two pools of resistin, the major one exists in specific granules, and the second on their cell membrane. Release of resistin from the neutrophil granules probably serves the main source of resistin at the site of inflammation.”-PubMed

Crohn’s, Colitis, Irritable Bowl Syndrome and other Intestinal Issues:

Perfect for a disease like Chron’s, “Lactoferrin also inhibits gut inflammation….”-Journal Of The American College of Nutrition

“The observation that lactoferrin can inhibit local inflammation by inhibition of TNF-{alpha} mediated immune responses predicts that lactoferrin exerts a similar antiinflammatory role at local sites of immune defense where the protein is expressed (e.g., the gastrointestinal tract, lung, uterus, etc).”-Journal Of The American College of Nutrition

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