The Curse of Fibrin

clotting

If Fibrin didn’t exist, we would bleed to death, literally. But when Fibrin goes awry, it can lead to a host of diseases including Rheumatoid Arthritis, Cystic Fibrosis, Pulmonary Fibrosis, Fibrocystic Breasts, Endometriosis, Fibroids, Thrombosis, Cardiovascular Disease, Liver Cirrhosis, Heart Disease and a host of many other diseases involving inflammation.

When Fibrin works as it should:

“Fibrin (also called Factor Ia) is a fibrous protein involved in the clotting of blood, and is non globular. It is a fibrillar protein that is polymerised to form a “mesh” that forms a hemostatic plug or clot (in conjunction with platelets) over a wound site.”-Wikipedia

When Fibrin is the bad guy:

Rheumatoid Arthritis:

“Recent research has shown that fibrin plays a key role in the inflammatory response and development of rheumatoid arthritis.”-Wikipedia

Scar Tissue:

Not all scar tissue is considered bad necessarily, but when it’s in your organs, it can lead to terrible problems.  And when it’s in your brain, it can lead to Multiple Sclerosis.

The below paragraph says that there are “no direct treatments for elevated levels”, meaning fibrin levels, yet anyone taking serrapeptase or studying alternative medications and diseases and knows about enzymatic therapy knows that you can reduce fibrin levels with certain supplements and can effectively reduce your CRP.  So why are so many doctors in the dark about this?

“Sometimes fibrinogen (the test) is ordered, along with other cardiac risk markers such as C-reactive protein (CRP), to help determine a patient’s overall risk of developing cardiovascular disease. This use of fibrinogen has not gained widespread acceptance though, because there are no direct treatments for elevated levels. However, many doctors feel that fibrinogen measurements give them additional information that may lead them to be more aggressive in treating those risk factors that they can influence (such as cholesterol and HDL).”-www.labtestsonline.org

“Fibrinogen is an acute phase reactant, meaning that fibrinogen concentrations may rise sharply in any condition that causes inflammation or tissue damage. Elevated concentrations of fibrinogen are not specific — they do not tell the doctor the cause or location of the disturbance. Usually these elevations in the fibrinogen blood level are temporary, returning to normal after the underlying condition has been resolved. Elevated levels may be seen with:

While fibrinogen levels are elevated, a person’s risk of developing a blood clot may be increased and, over time, they could contribute to an increased risk for developing cardiovascular disease.” –www.labtestsonline.org

If elevated fibrinogen levels are involved in inflammatory disorders, then here is a longer list of inflammatory disorders that would greatly improve with the direct decrease of fibrinogen:

“Abnormalities associated with inflammation comprise a large, officially unrelated group of disorders which underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. Non-immune diseases with etiological origins in inflammatory processes are thought to include cancer, atherosclerosis, and ischaemic heart disease.[4]

A large variety of proteins are involved in inflammation, and any one of them is open to a genetic mutation which impairs or otherwise dysregulates the normal function and expression of that protein.

Examples of disorders associated with inflammation include:

Allergies

An allergic reaction, formally known as type 1 hypersensitivity, is the result of an inappropriate immune response triggering inflammation. A common example is hay fever, which is caused by a hypersensitive response by skin mast cells to allergens. Pre-sensitised mast cells respond by degranulating, releasing vasoactive chemicals such as histamine. These chemicals propagate an excessive inflammatory response characterised by blood vessel dilation, production of pro-inflammatory molecules, cytokine release, and recruitment of leukocytes.[4] Severe inflammatory response may mature into a systemic response known as anaphylaxis.

Other hypersensitivity reactions (type 2 and type 3) are mediated by antibody reactions and induce inflammation by attracting leukocytes which damage surrounding tissue.[4]

Myopathies

Inflammatory myopathies are caused by the immune system inappropriately attacking components of muscle, leading to signs of muscle inflammation. They may occur in conjunction with other immune disorders, such as systemic sclerosis, and include dermatomyositis, polymyositis, and inclusion body myositis.[4]

Leukocyte defects

Due to the central role of leukocytes in the development and propagation of inflammation, defects in leukocyte function often result in a decreased capacity for inflammatory defense with subsequent vulnerability to infection.[4] Dysfunctional leukocytes may be unable to correctly bind to blood vessels due to surface receptor mutations, digest bacteria (Chediak-Higashi syndrome), or produce microbicides (chronic granulomatous disease). Additionally, diseases affecting the bone marrow may result in abnormal or few leukocytes.

Pharmacological

Certain drugs or exogenic chemical compounds are known to affect inflammation. Vitamin A deficiency causes an increase in inflammatory responses,[8] and anti-inflammatory drugs work specifically by inhibiting normal inflammatory components.

Cancer

Inflammation orchestrates the microenvironment around tumours, contributing to proliferation, survival and migration. Cancer cells use selectins, chemokines and their receptors for invasion, migration and metastasis.[9] On the other hand, many cells of the immune system contribute to cancer immunology, suppressing cancer.”-wikipedia

If you’re not convinced by wikipedia that too much fibrin is bad news, plenty of other good sources for information are out there, including pubmed.  Just do a quick google search on fibrin.

Hodgkin’s Disease: “Fibrin deposits were observed in the involved lymph nodes and/or spleens of 15 patients with Hodgkin’s disease by specific immunofluorescence and by electron microscopy. Two basic patterns of fibrin deposition were observed: 1) intercellular deposits, chiefly associated with nonneoplastic-appearing lymphoid cells and 2) deposits associated with the collagen fibers of young connective tissue. In addition, coarse fibrin deposits were observed in areas of necrosis, presumably a non-specific finding. Fibronectin was also observed in intercellular areas, but staining was less intense than for fibrin. Fibrin deposits were also observed in 3 of 6 cases of non-Hodgkin’s lymphoma, indicating that the finding is not an exclusive feature of Hodgkin’s disease. The pathogenesis and possible significance of fibrin deposition in Hodgkin’s disease are related to earlier observations of activation of the coagulation system on neoplasia and cell-mediated immunity and to the possible role of fibrin, fibronectin, and their breakdown products in angiogenesis and fibroplasia.”-pubmed

Multiple Sclerosis: “Tissue plasminogen activator (tPA), a neuronal as well as the key fibrinolytic enzyme, is found concentrated on demyelinated axons in multiple sclerosis lesions together with fibrin(ogen) deposits. The decreased tPA activity in normal-appearing white and grey matter and lesions of multiple sclerosis is reflected in diminished fibrinolysis as measured by a clot lysis assay. Nonetheless, peptide products of fibrin, including D-dimer, accumulate on demyelinated axons-the result of fibrinogen entry through a compromised blood-brain barrier (BBB). Analysis of tissue samples on reducing and non-reducing polyacrylamide gels demonstrates complexes of tPA with plasminogen activator inhibitor-1 (PAI-1) but not with neuroserpin, a tPA-specific inhibitor concentrated in grey matter. As total tPA protein remains unchanged in acute lesions and the concentration of PAI-1 rises several fold, complex formation is a probable cause of the impaired fibrinolysis. Although the tPA-plasmin cascade promotes neurodegeneration in excitotoxin-induced neuronal death, in inflammatory conditions with BBB disruption it has been demonstrated to have a protective role in removing fibrin, which exacerbates axonal injury. The impaired fibrinolytic capacity resulting from increased PAI-1 synthesis and complex formation with tPA, which is detectable prior to lesion formation, therefore has the potential to contribute to axonal damage in multiple sclerosis.”-pubmed

Since most of us are never ordered a fibrinogen test from the doctor, then my best assumption is that any tests that show an elevation of inflammation, would therefore mean that there is too much fibrin in the blood.  As you can see, too much fibrin results in inflammation and can lead to disease.  The only therapies that I know of that reduce fibrin are enzymatic therapies, which is why I take serrapeptase.   I prefer brands that are enterically coated.  Feel free to share your fibrin story.

Michael Jackson: Proof of a failed health care system?

While cardiologist Conrad Murray goes missing in action, authorities say the doctor, is not a criminal suspect.

“Craig Harvey, a spokesman for the Los Angeles County coroner, said there were no signs of foul play in the autopsy and further tests would be needed to determine cause of death. He said Jackson was taking some unspecified prescription medication but gave few other details.”

“We do not consider him to be uncooperative at this time,” Beck said. “We think that he will assist us in coming to the truth of the facts in this case.”-Huffington Post

Still you have to wonder, with Michael Jackson taking the precaution of having a live-in doctor, why is it that Brian Oxman thought this was bound to happen?

“I said one day we’re going to have this experience. And when Anna Nicole Smith passed away, I said we cannot have this kind of thing with Michael Jackson,” Brian Oxman, a former Jackson attorney and family friend, told NBC’s “Today” show. “The result was I warned everyone, and lo and behold, here we are. I don’t know what caused his death. But I feared this day, and here we are.”

Oxman claimed Jackson had prescription drugs at his disposal to help with pain suffered when he broke his leg after he fell off a stage and for broken vertebrae in his back.”-Huffington Post

Rumor has it that Michael Jackson was using the pain killer Demerol.

“The government warns that mixing it with certain other drugs can lead to reactions including slowed or stopped breathing, shock and cardiac arrest.”-Huffington Post

I know all to well how easy it is to trust that a doctor is looking out for you. When you have someone writing you prescriptions, you trust that they know what’s best. Someone like Michael Jackson probably never even thought about reading the warning labels on his medications. Why would he when he had his own live in doctor? I have to wonder if this doctor even considered his mental health, another problem with the health care industry. You would never have a psychologist sit down with the family doctor and discuss whether it’s safe to prescribe pain killers, and yet that’s the kind of health care I wish we had. Of course most people know MJ’s mental health is at least in question.  I think his doctor should have  thought twice about giving him pain killers but because this is a business, I’m sure most doctors in this position would do what they thought they needed to do to keep their job.  Enzymes could have been a great alternative to pain killers, which would have helped with pain, healing and inflammation.   It’s also nearly impossible to take too many. Not only that, his cardiovascular health would have improved! With such a simple solution, why was Michael’s health put in jeopardy?

For myself, I’ll still never forget being prescribed Sulfasalazine. I got the ok from both my gynecologist and rheumatologist that Sulfasalazine would not interfere with birth control pills, later to find that they do interfere with each other. So what does this mean? Do we have a failed health care system?

In my opinion, we absolutely do. Too many times have doctors failed me, and other people. How can a health care system work if it relies on profit? Healthy people are not profitable, and that’s just plain and simple. Cures are not profitable when there are many more medications that can manage a disease. I’m not saying that scientists aren’t searching for cures, but at the same time, I can’t trust a health care system that isn’t meant for everyone.

So yes, in my opinion I think that Michael Jackson’s doctor did fail him. Prescriptions shouldn’t be taken lightly and they shouldn’t be handed out like candy. You shouldn’t have to research your medications because you’re afraid your prescriptions aren’t compatible. You SHOULD be able to simply trust your doctor that he really knows what’s best for you. I hope that one day I’ll feel that way about doctors, that I can trust them fully and completely. And I hope one day I can trust my health insurance company (when I have one again) that they’re not going to drop my coverage if I forget to write that I was treated for acne as a child…..(and that was taken from a true story about a woman who got cancer but the insurance dropped her coverage because she failed to report her childhood acne prescriptions.) Life is short and without the best medical care, it can become even shorter.

Michael Jackson, your music was powerful and your talent, unforgettable. Rest in peace.

And for those of you that loved his music, here’s my favorite song, “It’s the Falling in Love”. I tried to find a better video that really represented this song…but this was the best I could find:

%d bloggers like this: