Low Dose Naltrexone and Why YOU Should Take It!

The Promise of Low Dose Naltrexone Therapy

Low Dose Naltrexone is taken in the form of 3mg to 4.5mg respectively speaking. It derives from the drug, Naltrexone which is taken in higher doses, generally around 50mg but can go up to 300mg. Though LDN comes from Naltrexone itself, it works in a completely different way, boosting the immune system. How does this non toxic drug work? When taken at bedtime, the body mistakes the low dose of Naltrexone as a brief blockade of opioid receptors. What this means is, your body thinks that something is trying to block it’s endorphins and thus, overcompensates, producing more.

“Naltrexone itself was approved by the FDA in 1984 in a 50mg dose for the purpose of helping heroin or opium addicts, by blocking the effect of such drugs. By blocking opioid receptors, naltrexone also blocks the reception of the opioid hormones that our brain and adrenal glands produce: beta-endorphin and metenkephalin. Many body tissues have receptors for these endorphins and enkephalins, including virtually every cell of the body’s immune system”-www.lowdosenaltrexone.org

A doctor named Dr.Bihari who graduated from Harvard had been working with patients who were taking heroin. Naltrexone prooved to be very successful in stopping heroin’s effects, basically in its tracks. Naltrexone is considered an “opioid receptor antagonist.” As time went on, Bihari’s research evolved. Some of his patients who had taken heroin had contracted HIV and so Bihari’s focus took a turn to help his suffering patients.

In 1985, Bihari discovered that a much smaller dose of naltrexone (approximately 3mg once a day) improved the immune system of a person with the virus HIV. As a neurologist, this discovery soon led to other findings. Not only did LDN help with AIDS patients, but has been said to help with Multiple Sclerosis, Parkinson’s, Cancer and other autoimmune diseases as well as Autism.

“LDN at bedtime each night is believed to produce a prolonged up-regulation of vital elements of the immune system by causing an increase in endorphin and enkephalin production.”-www.lowdosenaltrexone.org

I have been on LDN for 376 days now. I have greatly benefited from its effects. It did reduce an enormous amount of swelling. My blurry vision and chronic sore throat went away, along with my most painful symptom, Pleurisy. I survived on just LDN for almost a year, but decided to add Serracor-NK to the mix which has improved me to a point of near remission. I know several other people with Rheumatoid Arthritis that LDN has helped tremendously as well as a couple of people with Parkinson’s and many people with Multiple Sclerosis. Luckily the Internet provides the resources needed to learn about a drug and it’s effects, when otherwise I would have never known about it.

Because our bodies are so vastly different, it’s impossible to know for sure if LDN will work for you. But because LDN is virtually non toxic with side effects that are so minimal you may not even notice them, and they are likely to be gone within a week, such as insomnia, LDN is a great choice if you’re trying to reduce inflammation, boost the immune system, and stop or slow the progression of disease like Parkinson’s.

If LDN is such a low cost drug, ranging around $1 a day, why isn’t the information of LDN more widely spread? The reality is, pharmaceutical companies are big business. Autoimmune diseases have some of the most costly drugs offered as options. People spend thousands, if not hundreds of thousands of dollars on their health. Sick people keep pharmaceutical companies in business. It’s no surprise as well that a lot of drugs like methotrexate for example, can lead to horrible complications as well as injures your intestines. It makes perfect sense to me, to start with your least toxic options first and if they don’t work, then move onto other medications. Unfortunately, it’s not easy to get a doctor to prescribe LDN. Your best bet is to go through a neurologist because they are more likely to have heard of LDN or to seek out a naturopathic doctor.

Clinical trials are being studied at Universities, but most clinical trials are funded by big pharmaceutical companies. Because Naltrexone was already approved in 1984, a pharmaceutical company can’t reserve a patent on LDN and therefore can’t make big money. If money didn’t make the world go round and people’s health and wellness were really at the top of our priorities, I honestly don’t think so many people would be sick and there would be a cure for cancer.

80 Responses

  1. I am a 37 year old female from India. I would like to know whether LDN works by itself or it has to be taken along with any other RA drugs? As such i am following ayurvedic medicines for RA . I consulted many physicians for LDN , but no one seems to be interested in it, everyone suggested me for rheumatic conventional drugs. somehow got it prescribed from a local physician. Would be starting in a day or two. Can i start taking LDN in the absence of conventional RA medicines? What could be the dose to start with?

  2. Dear Sarah,
    I am 36, unmarried and diagnosed with Rheumatoid arthritis three years back. Don’t want to try the conventional RA drugs since I want to marry soon. Read about LDN and discussed with few physicians at my place. No one is willing to prescribe it. At present I am taking only ayurvedic medicines for my disease which is not very effective. Somehow got LDN from pharmacy. Starting it at my own risk and very curious about the end results. Wishing for a recovery through LDN. Would like to take only LDN without any other combination. Any advice for me?

  3. Can someone please provide a dr who can prescribe LDN in Vancouver.

  4. While it is true that such solutions can be quite effective
    and relatively safe, there are many reasons why you should consider natural psoriasis remedies as well.
    Also, a suppressed immune system, increase the risk of developing cancer.
    They are safe for daily use but may irritate if applied more than twice weekly.

  5. You ought to be a part of a contest for one of the finest blogs on
    the internet. I most certainly will highly recommend this blog!

  6. We are a group of volunteers and starting a new scheme in
    our community. Your site offered us with valuable information
    to work on. You’ve done an impressive job and our entire community will be thankful to you.

  7. Sarah, do you mind sharing the LDN dose you take & how soon before you started noticing positive effects? I got a prescription today.

  8. I lost link to this & just rec’d it today by chance. Update from when I posted in spring 2011 as i was researching LDN for severe inflammatory arthritis. I’ve been taking it 15 months now & I have steadily improved my health, lower levels in inflammation, used to be off the charts, last test was within normal range. I have my life back, I can now ride a bike, do long walks, am doing tai chi etc. I would highly recommend anyone to give this a try, ….vivid dreams are the side efffect, not destroyed livers etc. I also had a pharmacy give their 3 year student the job of doing a summary on this research info & I presented it to my doc. If anyone wants a copy, eme cvhoule@gmail.com

  9. Hi Alex,
    I am unsure if you happened upon this site because of Low Dose Naltrexone or not. Are you still taking Naltrexone? You may want to look into low dose naltrexone since you may still have naltrexone already. This will help normalize your natural ability to make opiods in the body, which could be why your knees are hurting. Look into the recipe of making your own, it’s surprisingly easy. 50ml tab = 50ml distilled water. (let dissolve and shake before each use. Refrigerate. -dosing- 3.5 ml before sleeping. I also recommend going to my “favorites” page on this blog and seeing if there’s anything there you would like to try.

    Naltrexone and Low dose naltrexone (LDN)are two separate things. It’s like comparing a bicycle to a motorcycle just because they have a couple of wheels. You simply can’t take the bike on the freeway or the motorcycle on the side walk, but you can certainly try. Naltrexone and Low Dose Naltrexone are not similar at all, so I I highly recommend that you learn about the differences, as LDN might really help you. It requires a lot of reading, too much to put in a reply post. You will need to google “naltrexone” and then google “Low Dose Naltrexone.” You will also need to read from several different sites on both topics. I hope that helps but if you have more questions, please let me know.

  10. Hi, I have been using naltrexone for 3 weeks now, to recover from an opiate addiction. Tonight my knee feels like it is on fire. Not painful to touch, just a throbbing pain keeping me from sleep. Anyone else experience this? Anyone know a remedy as no tylenol will help anymore :/ thanks,

  11. Hi Rose
    I would like to know where you got naltrexone overseas because I have been looking. I would appreciate the information. I live in Canada too. Patricia

  12. Thanks so much for giving everyone an exceptionally terrific chance to read in detail from this site. It’s usually very pleasant and also stuffed with a great time for me personally and my office co-workers to visit the blog at least thrice in one week to see the newest things you have got. And definitely, I am usually happy with the fabulous methods you serve. Certain 4 ideas in this posting are easily the most impressive we have had.

  13. I am not sure where in canada you live but
    Mcdonalds Pharmacy in Vancouver will compound it for you . Phone 604-872-2662. But I can’t find a Dr. that will prescribe the drug for me

  14. Hi colette, I to live in canada,Vancouver and would love to know if you know of anyone who would prescribe the drug. I have RA. Thanks Grace @ ggtuba@dccnet.com

  15. We’re a gaggle of volunteers and starting a brand new scheme in our community. Your site provided us with helpful info to work on. You have performed an impressive task and our entire neighborhood can be thankful to you.

  16. Low-dose naltrexone has been suggested as a treatment for multiple sclerosis, Crohn’s disease and fibromyalgia. However for many LDN is still seen as very controversial. The Patient Experience is running a research blog to find our your views on LDN and its value! Please drop round and tell your story!


  17. Colette,

    As far as I’m concerned, LDN raises endorphins and increases circulation. It’s like getting the benefits of exercise without the calorie burn or doing the work. I don’t see how these two effects would change how Humira works. Besides, the LDN prescription should be no higher than 3.0 or 3.5, so I don’t see how it could interfere with a tnf blocking agent. Just my two cents.

  18. Am going to be rx Humiral, i have a combo of RA and AS. My gp is willing to rx LDN, rheumy hadn’t heard of it & very skeptical. I read you shouldn’t take LDM if on a biologic, so not postive i can take it. I have a very short window like a week or 2 before i start the biolgic.

  19. Hi Emily,

    All inflammation is inflammation. I used to have a lump on my nose and lumps near my eyes. When my RA gets bad or in the past, my rosacea gets worse, it’s harder to breath, I might get blurry vision, nasal inflammation, hair loss and stomach issues, along with all the joint stuff. So just know that I “get it” and that I know your rhinitis is simply inflammation that needs to be in control. LDN would absolutely help. I believe from all that I have read and experienced, that LDN helps best with internal issues, and so I think you would have great success! You may also want to try Lactoferrin.
    thanks and hugs,

  20. Colette,

    Yes, I need to get on some postings! Thanks for waiting for a response as well! I was on Sulfasalazine for a while too, as well as mtx, but not leflunomide. IF you have to do a biologic, Kineret is your “safest” option. Alternatives are tricky, but I’m so happy I made this decision. I’m not against pharmaceutical drugs, but I am definitely for finding ways to live a better, healthier life. I love the book by Monica Reinagel! I hope you can get an rx of LDN. Just know that fillers are used in medications and even a filler can cause health problems. If you do get an RX (rather than diluting the medicine yourself in water), do make sure that the filler is something you normally don’t have issues with. Taking something everyday can easily cause problems. I found that out with yellow food dye! My RA was so terrible! So keep that in mind. Also, look into getting yourself some celadrin cream for your knees and elbows. The more you use it, the better it works. Strengthening the muscles around the joint will also act as a natural brace. As difficult as that might sound, keep that in mind! And wasting of muscles will also cause pain and inflammation, so don’t do yourself any favors by taking it too easy. Thanks so much for your comment and hope that you get an rx soon and start doing better! Also, I do hope you looked at my post on Serracor-NK, that’s an excellent supplement!
    thanks and hugs,

  21. The doctor thinks that I have non allergic
    rhinitis. I have chronic, miserable nasal inflammation with severe burining in my eyes.
    Would low dose naltrexone help me?

    Thanks for your reply!

  22. Hi, I’ve been researching like crazy & just came upon your site. I also have the diagnosis of seronegative spondylarthropy. Am on sulfasalzine & have been rx’d methrodextrate & leflunomide. Both of those gave me sever cognitive disfunction although it’s not on the list of reactions. Anyways, am sure biologics will be the next thing rx’d and I am desperately looking for alternatives. I’m in Canada, so if my gp or rheumy won’t rx LDN then i’ll try from other sources. I’m also doing the Inflammation Free Diet Plan, by Monica Reinagel. I have flare ups & swelling in my knees & elbows mostly. I would much rather ‘try’ this than the other toxic drugs that get prescribed. PS I don’t see any postings in 2011.

  23. Hi Sudeshna,
    Yes absolutely! You can always check out success stories on biomediclabs.com Wishing you the best of luck!

  24. My mom is suffering from pulmonary fibrosis. Her condition is serious. Does this Serracor-NK and Serra Rx really work on pulmonary fibrosis? Please reply me. Please…

  25. Hi Kimberly,
    I’m so sorry to hear that you are awaiting a diagnosis. I do not know anyone personally with MS that takes Serracor NK, however, if you have MS it would definitely be beneficial. There are times, and I shudder to say this, that I have thought maybe I have MS myself, and that the only reason why it’s only showing minor symptoms at times is because I am on the right medications, aka, LDN and Serracor. Because I don’t have insurance, I won’t know until then what my other symptoms that resemble something neurological and not RA, actually are.

    So just know that if you have MS, you are on the best stuff you could possibly be on. LDN can cause a relapse of symptoms and lots of people with MS go off of LDN. Those who stay on it discover that eventually they feel better than ever. And for most people, the relapse happens about the fourth month on LDN. Try and get yourself on a support group. There’s a great LDN support group on Daily Strength. Here you can talk about your symptoms, as well as your treatments. Here’s the link for you: http://www.dailystrength.org/groups/ldn

    Unfortunately, because you don’t know exactly what you have, it’s really difficult to know what you should do. If you have ALS, you will know sooner than later, and very high doses of co-enzyme q10 have been the only promising treatment that I know of as of yet. Serracor has co-enzyme q10, but not at the doses you would need if you do have ALS. I’m sure that’s probably not what you have though.

    Testing positive for Lyme can cause all sorts of problems and many people with autoimmune diseases originally tested positive for Lyme. You may want to add a couple of things to your supplement regimen, in case it’s MS or Lyme. I would add Turmeric, a spice many people with MS swear helps them. It’s anti-bacterial, fights inflammation and helps with intestinal health, a definite problem with MS. Another thing to consider would be Monolaurin, a supplement that fights viruses and bacterias. My favorite is Lauracidin, which is Monolaurin. It comes in pellets and is easy to swallow. It will also fight with inflammation and promote regular bowl movements. I like to buy mine from julianbakery.com But Monolaurin has lots of suppliers. A great way to get monolaurin is to drink coconut juice, and there are many great options out there these days. You can either buy the real coconut, or buy the juice. Try to find one that is pure in its ingredients, meaning it is just the coconut juice and nothing else. Sugar causes inflammation and will only make you worse.

    I hope that answers your questions and steers you in the right directions. You are definitely on the right things, no matter what you have. Keep up the good work, the positive thoughts, and you will get better.

  26. Hi,

    I was looking for a place to email you and could not find it sho I wanted to send you a message. I have been taking LDN and Serracor-Nk. No noted improvement yet..keeping my fingers crossed. I have not been able to get a diagnosis..I tested positive for lyme but after 6mon of iv antibiotics only got minimally better. They then thought it was ms..and now have been having bilatelral muscle weakness so they are looking at possibly als. I am only 34 so I have been trying everything possible to get better. I was wondering if Serracor NK helps anyone with MS?

    Thanks so much

  27. Cdn Reader,
    It is legal actually. Back in 1987 I believe is when Naltrexone was legalized. It’s fairly common to be given LDN if you have a neurological disease, and less common for anything else. Chrohn’s is another possibility. It’s simply not a standardized treatment for Rheumatoid Arthritis, or whatever it is that you have probably. But it’s legal, so don’t let anyone tell you otherwise. If you’d like to go to a homeopathic doctor, you may have better luck. Call around first and ask if they know about LDN. Many do prescribe it. I’m sure if you looked hard enough, you could find a doctor who would prescribe LDN. I don’t know if you have rheumatoid arthritis, but the problem is, it takes a lot of red tape to explain why you would need a medication that hasn’t been proven to help with RA. That’s why it’s so difficult. Perhaps if you refuse to take anything else, you might have something to stand on. I wish I had better advice. There are many other pharmacies online than riverpharmacy and I’m sure with a little research, you can find something that doesn’t require prescriptions and sends to canada.
    hope that helps!

  28. Because it’s not legal, that’s why! So they won’t give it to me.

  29. Their website is down, but that’s odd… you should be able to find another pharmacy, or why not just buy from a pharmacy near you?

  30. When I looked up River Pharmacy, the webpage said it wouldn’t ship Naltrexone TO Canada.

  31. Hi Maternson,
    Unfortunately, I have no idea where they source it. I wish I could tell you. Have you tried calling? I think there are cheaper ones out there…there was a pharmacy that I believe I bookmarked recently that looked cheaper. I could swear that they do say they ship from India and Mexico, and I don’t feel it’s dishonest of them…I never thought anything of it. The reality is, you cannot get medications in the U.S. without a prescription, and it is illegal to buy a medication with or without a prescription if you live in the U.S. and are buying overseas. So keep that in mind, when it comes to dishonesty. Unless you are living in that country, it’s illegal. I hope you get your questions answered!
    hugs and thanks,

  32. Sarah,

    I have seen you recommending River Pharmacy. Looking into them they do not ship the meds from Canada that’s just where their admin offices are. It says they are a “conglomerate” with several locations. This makes me think they likely ship from India or Mexico like many of the online pharmacies. But I have noticed their price for Naltrexone is pretty high. I have seen another LDN site recommend an Indian Pharmacy that sells it for about 10% of what River does.

    Do you know for sure where River sources? I don’t know how any of us can know the true potency of anything we order online and it frustrates me. I do think it is dishonest of River to insinuate they are a Canadian Pharmacy.

  33. Hi Ely,
    None of those should make you drowsy, in fact, all of them should give you a boost! You can have the Serracor-NK and Serra RX mailed to you in Canada, bulk would be the cheapest. The distributor that I use is biomediclabs. I really don’t know anything about Dimpro, only the brief description from looking it up. Vitamin D10 is new to me also, I had not looked it up until you told me about it. SO it sounds like you’ll have to buy from several different companies to get everything you need. Are you still taking Yasmin? It is under the opinion of some people that Yasmin isn’t a good choice, especially if you suffer from issues like fibroids. I hope you get everything under control and I wish you the best of luck. Please keep me posted!
    thanks and hugs,

  34. Hi Sarah,
    I read some comments and I decided to share my situation with u..I’d been diagnosed of having fibroids since year 2000 and some was removed when I delivered my son that same year.I had ultra sound in the past years and my Doctor said it’s still there,he then gave me Yasmin for a year but am worried cause I want to get rid of those fibroids without surgery.While searching on line I saw Serracor-NK and Serra RX 80,DIMPRO,Vitamin D10 which needs to be combined to balancce and normalize high levels of estrogen in the body..
    My question is if I can find those medicines here in canada without prescription,or what are other ways to get them?are those safe,I mean won’t make me feel drowsy after taking cause I’m looking after small children..
    Thanks so much and am waiting for your advise.More power.


  35. Hi Sharda,
    So sorry to hear. Just know I don’t have insurance either and haven’t for several years now. I do believe you can manage your RA fairly effectively with alternatives. You might want to try “celadrin” cream for your knee, as well as wrapping it with an ace bandage (when it’s not in use) to push the swelling out. Hot and cold therapy is also helpful. As you might know, I’m a big advocate on Serracor or SerraRX because inflammation means increased fibrin levels and these supplements directly reduce fibrin, making them unusually great.
    How to get your LDN? Well, just know that it’s considered illegal to buy LDN and have it shipped to the U.S. under U.S. restrictions. Obama is trying to have this changed however. Many people buy medicines from other countries all the time and get away with it, just know that I’m not advocating it, because it is illegal. There are many pharmacies that you can buy from online that won’t require a prescription… it is not illegal for them to do this because their laws are different from our laws. Make sense? riverpharmacy is an example of this. I’m not going to map anything out for you because it’s illegal and I can’t be giving out that type of information nor encouraging you to buy from another country. With that said, good luck!
    thanks and hugs,

  36. Hi Sarah,
    I was diagnosed with RA almost 3 yrs.I have been experiencing a lot of pain.I have a swollen knee right now and it is so painful.I don’t have insurance and my doctor dosen’t want to give me a prescription for LDN.I really need to know how i can get it .

  37. Hi Cindy,
    A neighbor asked me if I had tried Neprinol for RA. She was a crazy neighbor, but I looked into it anyway. I bought the product and it worked, until a few months later when the pills looked and smelled different because they were no longer enterically coating the enzymes, from what I believe to be true. That’s when I switched to Serracor-NK. Both products put me into a flare in the initial stages. Mine was about three weeks. To be honest, it was pretty brutal, BUT I increased the dose rather quickly which is probably why it happened both times…….I’m not very patient! If you want to avoid the flare, take a longer time to raise the dose of the pills.

    Mainly, Serracor-NK and Serra-RX reduce Fibrin. I was already interested in the enzyme Coenzyme Q10 when I came across Serracor-NK. Coenzyme Q10 is one of its ingredients. I had read in a magazine that people with autoimmune diseases are often lacking this enzyme. I also knew some information on Bromelain. So all in all, this product looked pretty good. Reducing Fibrin however, was extra intriguing. If you look up Fibrin, you will find all sorts of information on how it is one of the main contributors to Rheumatoid Arthritis. In fact, you can ask your doctor for a fibrinogen test. The fibrinogen test was created as a way to test inflammation levels, just like ESR and CRP are used as well. Though the test is out there and available, most doctors use the standard ESR test which is cheaper than CRP. Fibrin helps clot the blood but people with RA have too much Fibrin. That’s why people with RA are given a lot of blood thinners. Blood thinners however, don’t work in the same way as reducing fibrin in the body. Fibrin can store up in the body, causing nodules, tumors, cysts, varicose veins, and even plaque in the arteries.

    It’s my personal opinion that when you start Serracor-NK, the best thing to do is to continue taking blood thinners. You may even want to increase them slightly until all flaring is over, but this is just my opinion as I am no doctor. As the fibrin is pulled out of various parts of the body, it has to re-enter the blood stream which causes the flare. Just watch for bruising which could be a sign of too much blood thinners. Blood thinners include vitamin E, fish oil, NSAIDS, over the counter pain relievers and various other supplements and vitamins. Vitamin K helps clot the blood. Vitamin K also helps reduce inflammation. So if you do have worries of too much blood thinners, vitamin K is also another option. Just be aware that Vitamin K, along with vitamin A, D and E does store up in the body. I know it’s all a lot of information and a lot to balance but just pay attention to the body, take it slow and do lots of research! Serracor-NK works incredibly well for me, I highly recommend it! I hope that helps answer your question!
    hugs and thanks for visiting,


  39. Isabelle,
    I think throughout my blogs I kind of mention things here and there, but nothing really that explains my experience. Probably the closest post to what you’re looking for is, “Low Dose Naltrexone and Why You should take it.” I have certainly been meaning to really write about it though.
    I can tell you that there’s a couple of support groups online. One is in yahoo and one is in Daily Strength. A lot of people go into a flare at around the fourth month. There are lots of clinical studies on Crohn’s and HIV with LDN. Although many people will tell you not to take any immune suppressing drugs while taking LDN, I have seen a study about Crohn’s where participants stayed on drugs like methotrexate and there was a giant remission rate at around 85%. If you have any specific questions, feel free! I don’t know how many days it’s been but I could probably look back and figure it out. I think it’s been at least two years though of consistently taking it. I hope that helps!
    many hugs,

  40. hi

    is there a description of your starting ldn and your early experience with it written up somewhere?
    thanks for your site. lots of info.
    i have RA too.


  41. Hi Leke!
    (LDN) — Click for link.))

    I know what you mean with not having insurance! It’s terrible! MS in particular is a VERY difficult disease. Are you taking anything else? Check out this link too: (MS-alternatives) Other alternatives that I have heard were good for MS are magnesium and zinc which you may already be on? Also, you may want to check out a supplement called “Fibro Sleep“. It calms the digestive tract while reducing inflammation with herbs to help you fall asleep. I don’t know if melatonin is good for MS but the amount of melatonin in it is an extremely low dosage. Anyway, I hope LDN is the magic ticket for you! Let me know how it goes!
    many hugs,

  42. PLease e-mail that link where I can get LDN. I have MS and no health insurance. I am in desperate need to try it. Thank you so much in advance!


  43. Nicole,
    You can get LDN through your doctor. However, if you are in Canada, or if you’re not worried about transporting LDN from Canada then you can buy it from http://riverpharmacy.com But I will say that it’s considered illegal to buy pharmaceuticals of any kind from other countries. Hopefully this will one day change. I hope that helps you!

  44. Can you please post where I can get LDN, thank you :-)

  45. Hi Rose!

    Standard dose is 3.5mg. So if you take 1 of your 50mg tablets and dilute in 50ml of distilled water, then each ml equals 1mg of naltrexone. Make sense? Make sure it stays refrigerated. You will need a baby dropper with ml on the side for accurate measuring or you could use a teaspoon and guesstimate, although it would be far less accurate. Teaspoons hold 5ml.

    As far as sleep disturbances are concerned, that usually lasts around 3 days. If you’re really that concerned, you could start your LDN during the day time, however I do recommend going with the normal protocol which is at night. You could always start on the weekend as well. The only medicine that interferes with LDN is opioids. If you’re really concerned you could take a tylenol pm however I do recommend trying it without it first and trying it on the weekend. Here are a list of opioids that will interfere with LDN: http://medical-dictionary.thefreedictionary.com/Analgesics,+Opioid

    I hope that answers your questions and if you have any more, feel free to ask!
    many hugs,

  46. Dear Sarah,

    Thanks for your reply, I just got my naltrexone from overseas, but I haven’t start taking it since I don’t how much should I start. I also worry about sleep disturbance.


  47. Hi Rose,

    I’m pretty sure LDN will work with Sulfasalazine. I am so sorry to hear about your spondyloarthropathy. LDN is certainly worth a shot. Legally, you cannot buy Naltrexone without a prescription if you are in the U.S. even though it’s an anti-drug so to speak. However, if you are from another country or are not worried about legalities, you can get Naltrexone from http://riverpharmacy.com They come in 50mg tablets. One 50mg tablet is diluted in 50mg of distilled water. For each ml of water, it equals one mg of naltrexone. If you need more help with this let me know. The solution needs to stay refrigerated and only dilute one pill at a time because the solution is only suppose to last two weeks before you need a fresh mix again. I hope I’m making sense. I’m here if you need me!
    many hugs,

  48. Dear Sarah,

    First time I knew LDN from your website. I am so excited with this drug since I have seronegative spondyloarthropathy. I got knee arthritis since June 2009. I ‘ve done arthroscopy for my left knee but it doesn’t help at all. I can’t walk for long time and feel fatigue everyday. Now I take sulfasalazine 2 g/day for almost 3 months. But it seem don’t working yet. So I just want to know whether I can take this drug. I live in Indonesia. I can’t get this drug in here.

    Best regards,

  49. Hi Carey,

    I have known of people who took LDN during pregnancy and while breast feeding but at this time there are not any studies that I know of that test LDN during pregnancy. On the other hand, a High dose of Naltrexone (50mg) of Naltrexone is in the pregnancy category C. Prednisone is also in pregnancy Category C which means some risks. My personal opinion is that LDN because it’s such a minute amount and that because a large amount is Category C that it would make sense to say it is safe, however this is just my opinion as I am no doctor. It is also my opinion that Prednisone is not safe and I personally would not take it, even in a low dose. It has been known to cause cleft pallets in some children. Plaquenil is debatable as well because there are not enough studies on pregnancy and has been shown to cause some abnormalities when combined with other treatments. I am not one to just trust my doctor, so it is up to you to decide whether your doctor is looking at all the data or if they are just looking at you as a statistic. Sorry I couldn’t be of more help!
    Many hugs and best of luck to you,

  50. Hi Sarah,

    I am currently 5 weeks pregnant and have RA. I am taking plaquenil and a low does (2.5 mg) of prednisone. Do you know if LDN is safe during pregnancy? If not, do you know if it is safe during breastfeeding? I am worried about a post baby flare. I was diagnosed with RA 7 months after my first baby and have refused to go on strong medications because I want to continue to grow my family. I have been reading about the antibiotic therapy as well and am excited to try it and possibly the LDN once I am done having babies or maybe the LDN now. I am so excited to read about your success!! Thanks for sharing!


  51. Hi Eden,

    Yes I meant Suzanne Somers. ((woops, sorry)). Thanks so much for all the detailed info. You’ll have to let me know what you decide to do exactly. I’m scratching my head on this one.
    many hugs,

  52. Hi Sarah:

    Unrelated bloodwork (I hadn’t been to a doctor in many years) turned up that I was anemic with a high white cell count, which then led me to a hematologist/oncologist who diagnosed me with an enlarged spleen and lymphoma.

    Also, do you mean Suzanne Somers? She did beat cancer and had been an advocate for Iscador, widely used in Europe. I had been giving my dear late mother Iscador injections in her fight with cancer.

    PH is a lively topic—with experts not always agreeing on what is normal, or even how to best measure it. Blood and spinal fluid maintains a PH of about 7.4 or so, as I recall. Saliva and urine PH fluctuates. So far, after two days of testing, it still seems my PH is in a normal range.

    Be well,


  53. Eden,

    Since you are asymptomatic except for your spleen, how were they able to find what was really wrong?

  54. Nick,

    I am so sorry to hear! Have you not been able to get a prescription? Legally, you cannot buy Naltrexone without a prescription if you are in the U.S. even though it’s an anti-drug so to speak. However, if you are from Canada or another country or are not worried about legalities, you can get Naltrexone from http://riverpharmacy.com They come in 50mg tablets. One 50mg tablet is diluted in 50mg of distilled water. For each ml of water, it equals one mg of naltrexone. Keep refrigerated.

    Many hugs,

  55. Hi Eden,

    Thanks so much for the update! That is so strange that your ph is normal. I think you and all of us for that matter should all try and get our ph to a super healthy 7.5 but that’s just my opinion. I am glad you have the opportunity to experiment a little. You might want to look into Susan Summers. I have heard she knows and has written a lot on cancer and treatments. I can’t say for sure, but maybe it’s worth looking into. There was also an italian oncologist who believed that injecting cancer with baking soda changed the ph to alkaline and therefor got rid of it. There is heavy speculation on this of course. But it seems that there’s a lot of belief out there on ph so I’m still confused why your ph isn’t lower. Definitely, if nothing else, watch the documentary on “crazy sexy cancer” because this girl’s only choice was to experiment and she has successfully been able to get her cancer to stop growing through alternative treatments since she was unable to do the conventional treatments.

    Thanks again so very much for letting me know your update! Keep on posting and I look forward to hearing from you!
    many hugs,

  56. Hi Sarah:

    I began testing my PH the other day–and after several tests, the average (saliva and urine) so far is a bit over 6.5, which is a normal range based upon the formula given on this website


    I still don’t have a definitive diagnosis, but it is a rare combination: Non-Hodgkin’s indolent CLL and elements of other lymphomas. Since I’m asymptomatic (except for an enlarged spleen), I have a small widow to experiment. My plan is to begin taking LDN for three months, and see if it has a positive effect.

    Since I’m not on any other drugs, I’ll know whether the LDN is working for me. If not, I can still consider Rituxan. I’ll write again to report my progress.

    Be well,


  57. Can you tell me where I can obtain LDN 4.5mg pills? My sister is dying from stage 4 pancreatic cancer and as a last shot we have decided to try this regiment along with alpha lipoic acid.



  58. Thank you so much! Can you get my email off this website?


  59. Hi Mary,

    I’ll send you an email on how to obtain it.
    many hugs,

  60. How do you obtain your LDN?

  61. Hi Mary,

    Then yes, if he’s doing all of that, he ought to add on LDN as well. If he dilutes it himself which is really easy to do, he can take it as a liquid at night which I’m sure would be a relief from taking all the pills. It may really make the difference. I say hit this stuff hard with alternative treatments and once he gets to a point where everything is peachy, then he can cut back and see how he does. Just my opinion though.

  62. It is my father who has IPF and he has been taking Serracor-NK and Serra Rx, also N-Acetyl Cistene both orally and in the nebulizer. Also Vitamins D, C. etc etc.

    Thanks for your reply!


  63. Mary,

    Have you tried using enzymes yet?

  64. Anybody had any experience in using LDN in the treatment of pulmonary fibrosis? We are trying to find something that will help this terrible disease!

  65. Sarah:

    Many thanks for your thoughtful suggestions. I’m going to begin testing my PH right away. There’s a book titled, The Doctor Who Cures Cancer, that also delves into the importance of PH for health.

    I came across this book when I was researching ways to help my dear late mother who had colon cancer. Having gone through the ineffective, frustrating, and painful route of mainstream medicine in my mother’s illness, I learned that sometimes, as you well know, you have to become your own doctor.

    Be well,


  66. Eden,

    Wow, that is a shock! I think LDN is definitely a great choice, but I personally think it should be in combination with other things. Have you researched much on PH? I first really took a dive in interest with this when I watched, “Crazy Sexy Cancer.” You have to watch it. She’s amazing and funny. http://www.crazysexycancer.com/ Not only will you enjoy the documentary, but you will learn a lot. She goes through so much to get to where she’s at. Her cancer is untreatable with conventional meds. So imagine, not being given a choice and just deciding to learn everything you can. One of the points in the documentary that really changes everything is her PH. She goes to great lengths to change her PH. Now, mind you, PH balance is no easy task. I’ve been giving it kind of a go…well not a strong one but testing the waters so to speak with some liquid that changes the ph of your water. http://www.phionbalance.com/ph-balancing-products/ph+test You’re suppose to drink 8 glasses a day of ph balanced water. I probably get in three. Needless to say, my PH is still 6.5 only up from 6.0 which is not good. It should be 7.5 respectively. Here’s a decent website regarding ph. http://www.healingdaily.com/conditions/saliva-ph-test.htm Many sites claim that if your PH is alkaline, then cancer cannot exist and that those with cancer are very acidic, around 4.5. So it’s something to really think about. If I were you, I’d probably do both chemo and alternative therapies…..but I’m not you, so I don’t know.
    thanks so much for sharing and I hope to hear more about your journey. Please stay in touch and let me know what you think.
    many hugs,

  67. Hi Sarah:

    I have been recently diagnosed with Lymphoma—CLL most likely. A shock of the blue, as there were no symptom.

    An MD in Anthroposophic and homeopathic medicine suggested LDN as an adjunct to mainstream drugs—namely Rituxan and forms of chemo.

    I’m not sure what path to take yet—the path of least resistance would be LDN, as it does no harm, and it does seem to help some people.

    Be well,


  68. Hi Eden,

    It’s a secret! I’ll email you the link. :)
    Thank you so much for visiting my site and commenting! Do you have RA?

  69. Hi Sarah:

    Thanks for your brave and informative blog.

    Where are you obtaining low dose Naltrexone for $10 a month?

  70. Hi Jeremy!

    I don’t blame you for getting so excited about LDN. I was excited too when I first read about it. As you know, it has helped me a lot, but it’s no miracle cure for everyone. I never miss a day of taking it however because I do think it has really helped me. Combining it with other treatments I think is an excellent choice.

    I personally think it’s fine to take LDN with other medications. Many people out there will most definitely disagree. They will tell you that because LDN stimulates the immune system, that it will contradict other medications. The only one I would be weary of would be prednisone because since it’s a steroid, it sort of sloppily suppresses the immune system. Other drugs however, from what I have read, are more specific to what they suppress in the immune system. Many things suppress the immune system: lack of sleep, alcohol, poor diet, etc. Many things stimulate the immune system: sleep, healthy diet, vitamins, etc. LDN is specific in what it stimulates and promotes oxygen in the body, something we all lack with autoimmune diseases. It also reduces cytokines which cause inflammation. It is theorized that LDN helps at the cell level. So I think you are pretty safe in taking LDN with everything except for prednisone. I base this information partly on a study I read about Chron’s and LDN. The patients were asked to stay on their medications and take LDN at the same time. Some people were not on anything, while others were taking drugs such as methotrexate, prednisone and sulfasalazine. I believe the success rate for remission in that case study was somewhere in the 80’s percentage. To me, prednisone is the one drug I think you should try to wean yourself off of, eventually. You’re only on 5 which really is barely anything. But because it can cause bone deterioration, just keep that in mind and as you start to feel better, consider weaning one mg once a month or less depending on how you feel. I have heard that LDN makes antibiotics work even better. And sulfasalazine is part sulfa, part antibiotics. So right there, I think you’re on the right ticket. Make sure you have read all that you can about sulfasalazine. It can cause permanent eye damage but it is one of the least toxic drugs for RA and it’s the drug they trust more in Europe compared to methotrexate. I have been on it myself. If you do experience any eye changes, make sure to report them to your doctor immediately and you may want to take a couple of supplements that are specific for the eye. Please keep me posted!

  71. i am glad to have read the information on this site. thanks again for the info. like katie above i am 32 and have had RA since i was 26. I don’t want to get to excited by all the information on ldn i have found but i can’t help it. i am going to try this asap. it’s a heck of alot safer than the other drugs i have been taking just to be able to function. I was wondering though sarah if i can take ldn while still on sulfasalazine and 5 mg prednisone, or if theyu will just counteract one another. thanks again for the info…

  72. Hi Sheryl,

    It’s really tough to find information on LDN and animals, however some people have tried it with their dogs with great success. I have heard that it’s 1ml for a medium sized dog. For a cat, I would suggest much less than that, perhaps just a couple of drops to start and see how your cat reacts that evening. I would imagine that because cats sleep as much as they do, the effect of LDN could be very substantial. Make sure you get blood tests before and after and you may even want to consult with a veterinarian, not to get a prescription, but to be a helpful observer. In all honesty, I think this is pretty new territory to try but if I had a cat who was having health issues and there weren’t many options, I would give it a shot. Get a baby dropper from the store and literally just try two drops the first night, observing your cat that evening and the next day. The easiest way to administer would probably be in a can of wet cat food. Other than that, perhaps if you look hard enough, you could find forums that where people have tried it. It’s really a hard decision since a cat cannot tell you how they feel. You may want to look into a feline’s endorphin production and see how and if it is similar at all to a human’s. Because of their size, I would never go more than 0.5ml which, to put into perspective, 1/4 teaspoon is 1.25ml, so it’s a fraction of this. Good luck to you and sorry I couldn’t be of more help! Let me know how things go! There is an LDN group on both yahoo groups and Daily Strength where people may have more information for you.

  73. What about using LDN in a cat with feline HIV. Has this been tried?

  74. Hi Kati,
    Of course! You’re right, there is very little info out there on LDN and RA. I’m on Daily Strength, a support group. At the time that I wanted to try LDN and started talking about it, two other women on Daily Strength decided to go for it. One of those girls also wasn’t having results from Enbrel. The other one had had RA for 10 years and tried multitudes of drugs which all worked to different degrees. She was one of those people that was up for experimenting and liked the idea of taking something unharmful. She also figured during the time she was experimenting with LDN, that if nothing else, she was giving her liver a well needed break. Long story short, she ended up in remission on LDN alone. The other girl was on LDN for six months before it started to work. About four months later, she decided to add on another drug which was minnocycline. She went into permanent remission (no drugs needed at all at this time). I decided at that time to also add something to LDN because even though LDN was VERY helpful in reducing inflammation, it still wasn’t the kung-pow remedy I was searching for. And knowing that with RA, you often do “stack” medications, it only made sense that I needed something more BESIDES LDN. That’s when I started on Serracor-NK and you can click the word to find the supplement. It’s an enzymatic formula. It works EXTREMELY well with RA, no doubt. The only thing to be aware though with any natural remedy, including LDN, antibiotic therapy and Serracor-NK is that most people end up flaring until they get better. It’s called “hering’s law”. For instance, the girl who took LDN, her name is April and she was the one who took the antibiotic therapy with it…anyway, she flared on LDN for at least two months. I flared on Serracor-NK for probably a few weeks to a month and then I got dramatically better and the effects were rapid. Then there are some people who never flare. It’s all very individual. I had advised one person to take both at the same time. But she was flaring so badly that maybe better advice is to take just one and then the other. I guess it depends if you want a break between flares or get it all over with. I hope this all made sense and feel free to ask me more questions.
    many thanks,

  75. Sarah,

    I have RA, and I would love to hear your story. My hubby and I are excited about what we’re reading regarding LDN, but so far I find mostly anecdotal evidence that it helps MS a great deal. I’m desperate to hear from people like yourself that have RA, and find out specifically how did LDN make a difference in your symptoms.

    My RA is NOT responding to the TNF inhibitors at this time. I’m only 34. I’ve had RA since I was 28. I have a 3 year old son, an MA in counseling, but I’ve had to give up my career. I’m desperate to go back.

    Oh – and what is that other drug you mentioned. I’ve never heard of it. Is there any way you could email me and let me know where I could read about your story or if you could answer my questions.

    Thank you,
    – Kati

  76. Hi Michael,

    :) Your comments made me smile. It’s always nice to hear people doing well on LDN. I think LDN is particularly great if you have MS or a Neurological disease like Parkinson’s. So are you taking LDN? LDN was the first medication that taught me to actually give something a try rather than worrying about it sounding “too good to be true.” It was my “gateway drug” in that sense because had I not tried it first, I may never have tried Serracor-NK. These two things have made a remarkable, unbelievable change with my disease Rheumatoid Arthritis. I expected LDN to change my thyroid but it never did. I think because it modulates your system and because I supplement thyroid, that this is why it’s never changed how my thyroid functions.
    Thanks so much for the comments and I would love to hear more of what brought you to this site.
    many thanks,

  77. Sorry, I just posted about LDN and now find that you have indeed discovered it. I have personally seen a woman that was wheelchair-bound with MS now be able to drive, do all the other things, and the wheelchair is laying in the garage as a reminder of the days before LDN.
    So certainly, count my posts as a “never mind”. Glad you’ve
    already found LDN.

  78. Billy,

    That’s great news! Do you take it for MS, RA, Parkinson’s or Chrohn’s or something else? Please share your story! Thanks so much!

  79. i have been taking ldn for a year feel great

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: